Endocrine Abstracts

Introduction: Given the importance of establishing a reliable diagnosis of impaired glucose metabolism and diabetes mellitus (DM), knowledge on accurate and reproducible parameters is needed. However, little is known on the reproducibility of fasting and oral glucose tolerance test (OGTT) derived parameters, especially with respect to the 2-hour derived parameters.Objectives: To determine reproducibility of parameters of glucose metabolism in a non-diabe...

Background: Obesity associates with co-morbidities as non-alcoholic fatty liver disease (NAFLD). Obese men often present with low testosterone (T) levels. As sex steroids undergo hepatic metabolization and their serum levels depend on hepatic sex hormone binding globulin (SHBG) secretion, NAFLD could contribute to this phenomenon. Previous studies however were contradictory and not based on state-of-the-art technology as mass spectrometry or biopsy-proven NAFLD.<p class="a...

Aims: Emerging data indicate that an impaired release of adipose tissue-derived adipokines could play a pivotal role in the development of non-alcoholic fatty liver disease (NAFLD). We aimed to evaluate whether circulating levels or visceral adipose tissue (VAT) expression of recently described adipokines associate with the histopathological disease severity and thus may contribute to the progression of pure fatty liver into an inflammatory and insulin resistant NASH status.</...